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Characteristic Spectral Features of the Polarized Fluorescence of Human Breast Cancer in the Wavelet Domain

Volume 66, Number 7 (July 2012) Page 820-827

ANITA H. GHAREKHAN, NRUSINGH C. BISWAL, SHARAD GUPTA, PRASANTA K. PANIGRAHI, and ASIMA PRADHAN


Wavelet transform of polarized fluorescence spectra of human breast tissues is found to localize spectral features that can reliably differentiate normal and malignant tissue types. The intensity differences of parallel and perpendicularly polarized fluorescence spectra are subjected to investigation, since they are relatively free of diffusive background. A number of parameters, capturing spectral variations and subtle changes in the diseased tissues in the visible wavelength regime, are clearly identifiable in the wavelet domain. These manifest both in the average low-pass and high frequency high-pass wavelet coefficients.



Index Headings: Florescence spectroscopy; Wavelet transform; Biomedical optics; Breast cancer.