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Surface-Enhanced Raman Scattering: An Emerging Label-Free Detection and Identification Technique for Proteins

Volume 67, Number 4 (April 2013) Page 355-364


The detection and identification of biologically important molecules has critical importance in several fields such as medicine, biotechnology, and pharmacology. Surface-enhanced Raman scattering (SERS) is a powerful emerging vibrational spectroscopic technique that allows not only for the characterization, but also for the identification and detection of biomacromolecules in a very short time. In this review, efforts to utilize SERS for label-free protein detection and identification is summarized after a short introduction of proteins and the technique.

Index Headings: Surface-Enhanced Raman Scattering; Proteins; Label-Free; Detection; Identification.