The following is an abstract for the selected article. A PDF download of the full text of this article is available here. Members may download full texts at no charge. Non-members may be charged a small fee for certain articles.
Spectroscopic Characterization of Poly(Amidoamine) Dendrimers as Selective Uptake Devices: Phenol Blue Versus Nile Red
Volume 60, Number 5 (May 2006) Page 551-559
Morgan, Elizabeth J.; Rippey, Julie M.; Tucker, Sheryl A.
Selectivity of amine-terminated poly(amidoamine) (PAMAM-AT) dendrimers as host molecules for phenol blue and Nile red guests was investigated using absorption and fluorescence spectroscopies. Phenol blue has been known to associate near the core in the PAMAM-AT dendrimers. Nile red has also been shown to associate with this dendrimer family; however, this occurs in the outermost branches. Concentration ratios and generational dependencies were investigated. It was found that phenol blue was sequestered in the PAMAM-AT dendrimers in the presence of the interfering Nile red, and this association appeared to be the same as that of PAMAM-AT with phenol blue alone. As the concentration of Nile red increased relative to the concentration of phenol blue, the desired association of phenol blue became increasingly hindered. While the presence of Nile red did affect association, phenol blue still had considerable association even when Nile red was in ten-fold excess. The association of phenol blue with PAMAM-AT was stable and robust; however, Nile red's association was relatively weak and unstable.