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Simplex Optimization of Experimental Factors in Atomic Absorption Spectrometry

Volume 29, Number 5 (Oct. 1975) Page 429-433

Parker, L.R.; Morgan, S.L.; Deming, S.N.

Atomic absorption (AA) methods of analysis are subject to the influence of many experimental factors such as fuel and oxidant flow rates, burner height, and lamp current. The optimization of these factors and the corresponding improvement of response are integral parts of the development of AA methods. The importance of the systematic improvement of response was recognized by Cellier and Stace, who used sequential factorial designs to increase analytical sensitivity. Parsons and Winefordner considered the theoretical significance of various experimental factors and also employed factorial designs to achieve improved response. Other researchers have used similar statistical approaches in the development of AA methods.