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Fluorescence Quenching Investigation of the Complexes of Dibenzofuran with Natural Cyclodextrins

Volume 56, Number 11 (Nov. 2002) Page 1490-1497

Rodríguez, Pablo; Sánchez, Miguel; Isasi, José Ramón; González-Gaitano, Gustavo

The steady-state fluorescence of dibenzofuran (DBF) in aqueous solution is quenched in the presence of natural cyclodextrins (CDs), α, β, and γ-CD. The decrease in the fluorescence is static in nature for all the macrocycles and follows as a result of the formation of inclusion complexes of dominant 1:1 stoichiometry. With γ-CD, excimer emission is detected at high CD concentrations due to the formation of a complex of 2:2 stoichiometry, DBF2 : γ-CD2. The binding constants have been determined from the fluorescence intensities through the analysis of the F0/F vs. [CD] plots, resulting in a stronger association for β-CD. The thermodynamic parameters of the binding, enthalpy and entropy, have been calculated from the temperature dependence of the formation constants. The different trend displayed by α-CD, in both the absorption and fluorescence spectra, seems to be related to a shallow inclusion of DBF, stabilized by hydrogen bonding between the oxygen atom of the furan ring and the hydroxyl groups of CD.