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Separation and Identification of Sulfonamide Drugs via SFC/FT-IR Mobile-Phase Elimination Interface

Volume 51, Number 12 (Dec. 1997) Page 1791-1795

Ashraf-Khorassani, Mehdi; Combs, Michael T.; Taylor, Larry T.; Willis, Jim; Liu, Xiaojun; Frey, Charles R.


Packed-column supercritical fluid chromatography with a mobilephase gradient of carbon dioxide and methanol has been performed on a mixture of eight sulfonamides. The analytes were detected and identified with Fourier transform infrared spectrometry. A commercial mobile-phase elimination interface (LC-Transform ) was employed. A fixed-integral restrictor afforded the decompression zone between the column and germanium disk where the analytes were deposited. Excellent-quality infrared spectra were obtained for all eight separated analytes.