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Use of Shift Reagents to Determine Enantiomers by Near-Infrared Analysis

Volume 50, Number 9 (Sept. 1996) Page 1161-1164

MacDonald, Stacy A.; Hieftje, Gary M.

A method is described that utilizes β-cyclodextrin and silica gel as shift reagents to distinguish between enantiomers by means of near-infrared transmission spectroscopy. The premise is that the spectrum of the (+)-enantiomer bound to the shift reagent will be different from that of the (−)-enantiomer bound to the same reagent. With the use of principal component analysis, the difference between the enantiomers can be distinguished. The resulting method is fast, simple, and of potential application in pharmaceutical process control.