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Use of FT-IR Internal Reflection Spectroscopy in Combinatorial Chemistry

Volume 50, Number 4 (April 1996) Page 532-536

Gremlich, H.U.; Berets, S.L.

Combinatorial chemistry technologies for new-lead discovery and lead optimization have recently captured the imagination of the drug-discovery community. With the use of solid-phase synthesis on polymer substrates, vast numbers of molecules, so-called chemical libraries, will be readily accessible by these combinatorial approaches as potential sources of new leads for drug discovery.