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Transmission FT-IR Spectroscopy Applied to the Determination of Hydrocarbon Residues on Pharmaceutical Process Equipment

Volume 49, Number 4 (April 1995) Page 540-541

Severdia, Anthony G.


In the course of operating process equipment in the pharmaceutical industry, it is necessary to assure that all product contact surfaces of process equipment contain a minimum amount of residue. The residue may be another product remaining from a previous operation, an excipient, or a "nonformulation" type of material. This report discusses the determination of hydrocarbons, in the form of lubricating greases, on the product contact surface of various tablet presses by use of FT-IR spectroscopy. The FT-IR spectroscopic method provides for both identification and quantitation of the lubricant and was suggested by an EPA method.