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Micron Surface-Enhanced Raman Spectroscopy of Intact Biological Organisms and Model Systems

Volume 48, Number 5 (May 1994) Page 545-548

Todd, Elizabeth A.; Morris, Michael D.

Surface-enhanced Raman spectra have been obtained within intact zebrafish embryos and inside the 500-fL pores of a Nucleopore filter membrane with the use of coated microelectrodes with 1-3 μm active silver tip diameters. The spectra obtained demonstrate the microelectrode's ability to penetrate biological membranes as well as restricted volumes.